Engineering pH responsive fibronectin domains for biomedical applications
نویسندگان
چکیده
منابع مشابه
Engineering pH responsive fibronectin domains for biomedical applications
BACKGROUND Engineered antibodies with pH responsive cell surface target antigen-binding affinities that decrease at the acidic pH (5.5-5.8) within the endosomes have been found to have reduced susceptibility to degradation within the lysosomes and increased serum half-life. Such pH responsive recombinant antibodies have been developed for the treatment of cancer and cardiovascular disease. Engi...
متن کاملElectro-responsive Hydrogels for Biomedical Applications
Smart biomaterials hold great potential for many biological applications in regenerative medicine. In this field, we aim to develop a novel electro-responsive PolyPhosphoEster (PPE) based hydrogel. This hydrogel can transform electrical energy into conformational changes of the structure when exposed to an electrical field (Fig. 1b). These hydrogels have high potential, allowing development of ...
متن کاملStimuli-Responsive Nanomaterials for Biomedical Applications
Nature employs a variety of tactics to precisely time and execute the processes and mechanics of life, relying on sequential sense and response cascades to transduce signaling events over multiple length and time scales. Many of these tactics, such as the activation of a zymogen, involve the direct manipulation of a material by a stimulus. Similarly, effective therapeutics and diagnostics requi...
متن کاملSurface Engineering of Multifunctional Nanocomposites for Biomedical Applications: a Brief Update
Context: In recent years, nanotechnology has opened up several new avenues of extraordinary biomedical potential by modulating metals into their nanosize leading to significant improvement in their chemical, physical and optical properties. Introduction: <span style="color...
متن کاملStimuli responsive polymers for biomedical applications.
Polymers that can respond to external stimuli are of great interest in medicine, especially as controlled drug release vehicles. In this critical review, we consider the types of stimulus response used in therapeutic applications and the main classes of responsive materials developed to date. Particular emphasis is placed on the wide-ranging possibilities for the biomedical use of these polymer...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Engineering
سال: 2015
ISSN: 1754-1611
DOI: 10.1186/s13036-015-0004-1